Physiological function of Nickel
Sensitization: Nickel is the most common allergenic metal, about 20% of people allergic to nickel ions, the number of female patients is higher than the male patients, contact with human body, nickel ions can penetrate through the pores and sebaceous glands To the skin inside to cause skin allergies, the clinical manifestations of dermatitis and eczema. In the event of sensitization, nickel allergy can often continue indefinitely. Patients suffer from stress, sweat, air and skin humidity and friction will increase the symptoms of nickel allergy. Nickel allergic dermatitis clinical manifestations of itching, papular or papular vesicular dermatitis, accompanied by mossy.
Clinical observations: In higher animals and humans, the biochemical function of nickel has not been well understood. But in vitro experiments, animal experiments and clinical observations
provide valuable results.
1. In vitro experiments showed the affinity of nickel thiamine pyrophosphate (carboxylase), pyridoxal phosphate, porphyrin, protein and peptide, and demonstrated that nickel also binds to RNA and DNA.
2. Nickel-deficient hepatic dehydrogenase decreased, including glucose-6-phosphate dehydrogenase, lactate dehydrogenase, isocitrate dehydrogenase, malate dehydrogenase and glutamate dehydrogenase. These enzymes are involved in the production of NADH, anaerobic glycolysis, the tricarboxylic cycle and the release of nitrogen from amino acids. And lack of nickel shows changes in the structure of liver cells and mitochondria, especially within the network of irregular mesh, mitochondrial oxidation decreased.
3. Anemia patients with reduced blood levels of nickel, and reduced iron absorption, nickel has the role of stimulating hematopoietic function, human and animal supplementation with nickel increased red blood cells, heme and leukocytes.
Physiological needs: As dietary daily intake of nickel 70 ~ 260μg / d, human needs are based on experimental results of animal projections, may require 25 ~ 35μg / d.
Excessive performance: daily intake of soluble nickel 250mg can cause poisoning. Some people are more sensitive, intake of 600μg can cause poisoning. According to animal experiments, chronic overdose or overexposure can lead to degeneration of myocardium, brain, lung, liver and kidney.
Data show that: daily drinking high water containing nickel will increase the incidence of cancer, especially in cancer patients have to put an end to the exposure to nickel during radiotherapy and chemotherapy. Market distribution of some ceramic utensils should be carefully chosen to use, usually take a nickel-containing ceramic life with drinking appliances, will increase the chance of onset.
In addition, there are some non-formal manufacturers of sex medicines also have a high nickel content. Therefore, nickel and personal health should attach great importance.
Deficiency: animal experiments show that lack of nickel can appear slow growth, decreased fecundity.